The Europeans made money with furs, fish, and tobacco. The Spanish made a lot of money in gold and silver but there was not much gold in the American colonies.
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The inhabitants of the New World had no resistance to new diseases brought by the Europeans. -APEX
With the understanding that Mexico is in North America, Native Americans did not have the diseases that Europeans brought to the New World. Also, horses and the wheel were not in the Native American empires and Tribes.
New Amsterdam in Manhattan is the name that was giving by Europeans. This was not a well populated city.
New food sources
If you're in America then there are a few ways. Up north in new England then you would make your money fishing and cutting down hardwoods for English ships. if you were in the Atlantic states you would be planting and selling tobacco. if you were in New York, jersey, and massachusets you would be getting lobsters and cutting down trees.