Pearl S. Buck was the first woman to win the Nobel prize for literature
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Jeanette Rankin was elected by the state of Montana and was the first woman elected to Congress.
Mary McLeod Bethune was the first African American woman to head a federal agency
Kalpana Chowla. She was, not only the first American-Indian in space, but the first woman in space as well.
Shirley Anita Chisholm became the first black woman elected to the United States Congress in 1968.
Elaine Chao, Secretary of Labor for George W. Bush was of Chinese descent and is the first of Asian ancestry.