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The first permanent settlement was made in 1769 in the Watauga River valley of East Tennessee, with a name unknown. But, the oldest town in Tennessee is Jonesboro, which was founded two years after that first permanent settlement was made. I would answer with Jonesboro.
East Asia
The reasons the Europeans wanted to find a route to the far east is because they wanted to expand their trade profits
The Great Northern European Plain encompass portions of the following countries: England France, Belgium, The Netherlands, Germany, Poland, Denmark, the Czech Republic, and Sweden. This plain continues and is then called the East European Plain.
Ferdinand Magellan Ferdinand Magellan's expedition of 1519-1522 became the first expedition sailing west from Europe to Asia, and the first to cross the Pacific. It also completed the first circumnavigation of the earth. The first to circumnavigate the globe, which Drake also did, was the Magellan expedition. Magellan