Since they are both rivers they allowed boats to carry goods.
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The River Nile, The Tigris-Euphrates river basin, and the River Jordan all play roles in the hydro-politics of the Middle East. Water politics play an important role in the desert region.
They didn't play a role in "global trade." First, there was no global trade as we think about it. Second the British passed the navigation acts which meant that they could only by and sell to the British. Smuggling took place and Dutch tea was brought in as well as items from France.
The southern states were apposed to the abolishment of slave trade and slavery. This one of the major reason for the escalation of the war.
The Silk Road increased trade between Asia and Europe.
michigan did play a role in the revolutionary war:)