John Tyler was the first Vice-President to take over after the death of a sitting President. William Henry Harrison was sworn in as President on March 4, 1841. He became ill with symptoms resembling a bad cold about three weeks later. On April 4, 1841, Harrison died of what is believed today to have been viral pneumonia. Thus, after one month in office as Vice-President, John Tyler assumed the presidency. He officially took the oath of office on April 6, 1841. He served one term in office until March 1845.
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The first vice president to take over office was John Tyler.
If the president cannot perform his duties for any reason the Vice President assumes the Presidency. If the Vice President cannot perform the Speaker of the House assumes the duties of the President
Vice President Speaker of House of Representatives President Pro Tempore of Senate Secretary of State Secretary of treasury Secretary of Defense
The vice president is "only a heart-beat away from the presidency". As such, it is well for him to be well informed about the President's plans and initiatives, so that he can take over seamlessly , should it become necessary.
The twenty-fifth Amendment allows the Vice President to take office, and allows the President to temporarily give up his powers, and later retake them, and allows the Vice President and Cabinet to collectively temporarily remove the President, and Title 3 of the United States Code, section 19 specifies an order of succession for the cases where the President and Vice President are both unable to serve. Despite common belief, neither the Constitution nor the twenty-fifth Amendment allows the Speaker of the House or the President pro tempore of the Senate to take office.Article 2, section 1, of the Constitution of the United States of America allows the Vice President to take the duties, but not the office, of President.