His wife and child were murdered by Red John, a cereal killer who paints a smiley face with the victims blood near the body. Jane has been hunting him since then to finally avenge his loved ones.
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HE did not die from anything. He was murdered by his wife, Clytemnestra.
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they all die
A centaur offered to help him and his wife cross a river. Heracles had to cross the river while his wife went over with the centaur. the centaur tried to run off with his wife but was shot by a poison arrow. the centaur took off his fur and told the wife to give it to Heracles's. Later when the wife heard he was cheating on her, she sent the fur to him and he died from the poison still on it.
Supposedly his wife and some of his ministers killed him, but for what reason I don't know.