The Akkadians developed a Golden Age of Persian culture. The Akkadian language spread beyond the boundaries of Mesopotamia. Their manner of writing served as the model for many inscriptions. Their sculpture, particularly in the round relief form, was highly prized.. They also developed the first postal system using clay tablets.
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Alexander consciously set out to Hellenise it. He established a hundred cities in the Greek tradition (most named Alexandria) as centres of Greek-style culture, with gymnasia, temples, architecture etc and citizenship rules. He married his generals to Persian women and brought the Persian aristocracy into his armies. Greek became the lingua franca of commerce. This provided a veneer of Greek civilisation which lasted until the collapse of the Hellenistic kingdoms established by his successors and the encroachment of Islamic culture.
It essentially became a standoff - after the Greeks repelled the Persian attempt to incorporate them into the Persian empire, a peace was arranged and the Greeks went back to fighting each other. The Persian empire continued on until over-run by Macedonia.
Kushite culture became more like Egyptian culture.
He continued his father Philip's plan to take over the Persian Empire.
Olmec was the "mother" culture of Mesoamerica. Many aspects of their culture such as gods, glyphic writing and artistic forms became parts of later civilizations such as the Maya and Aztecs.