The Egyptian civilization was once one of the worldâ??s great empires and one of the most advanced. There is not one specific event that lead to the decline. It was the unfortunate corruption, mismanagement and lack of investment into the country that cause their problems.
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The Spaniards led to the decline of the Inca civilization. The Spaniards took Atahualpa (ruler at the time,) hostage and killed his brother Huascar. Then they installed a new leader Atahualpa's brother, Manco Inca. He eventually passed on the throne to his son Tupac Amaru. When the Spaniards captured and executed him, the Inca's resistance to the Spaniards ended.
The Aztecs had a lot of enemies and when the Spanish conquistadors arrived to Mexico the Aztec enemies were more than happy to help the Spanish destroy the Aztecs.
The period of disorder after the decline of the Roman Empire led to an extended period of disunity during the Middle Ages that was characterized by feudalism.
The Incas declined because the Spanish that invaded their land killed them and used them as slaves, also because since the Incas were not immune to the Spanish diseases they brought, most of them died.
It's takeover by Alexander the great.