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Sargon of Akkad was the first person to unite and reign over Mesopotamia. Mesopotamia was the first empire in the world.
The ruler of the first empire was King Sargon of Akkad.he created the Akkadian empire
Sargon, leader of the Akkadian Empire, was the first person to establish the first empire.

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The first ruler of Early Dynastic Period was Gilgamesh of Uruk (legendary) - 2700 B.C. The first ruler of Dynasty of Akkad (Agade) was Sargon - 2340-2285 B.C. The first ruler of Dynasty of Lagash was Gudea(1) - 2150-2125 B.C. The first ruler of Third Dynasty of Ur was Ur-Nammu - 2112-2095 B.C. The first ruler of Dynasty of Isin was Ishbi-Erra - 2017-1985 B.C. The first (and only) ruler of Dynasty of Larsa was Rim-Sin - 1822-1763 B.C. The first ruler of The Old Babylonian Dynasty was Sin-muballit - 1812-! 1793 B.C. The first ruler of Babylonian Dynasty was Nabu-mukin-zeri - 731-729 B.C. The first ruler of Neo-Babylonian Dynasty was Nabopolassar - 625-605 B.C. The first ruler (and only) of Old Assyrian Dynasty was Shamshi-Adad - 1813-1781 B.C. The first ruler (and only) of Dynasty of Mari was Zimri-Lim - 1775 B.C. The first ruler of Middle Assyrian dynasty was Ashur-uballit I - 1365-1330 B.C. The first ruler of Neo-Assyrian dynasty(2) was Ashurnasirpal II - 883-859 B.C. The first ruler of Achaemenid Persian dynasty was Cyrus II the Great - 559-530 B.C.