Their enemies were the Titans:
The Males:
Oceanus
Hyperion
Lapetus
Cronus
Crius
Coeus
The Females:
Tethys
Theia
Phoebe
Themis
Mnemosyne
Rhea
They are the children of Ouranos (sky) and Gaia (Earth). They were led by Cronus, who was the youngest. They came before the standard Greek Gods, in fact they spawned the Greek Gods. Cronus spawning perhaps the three best known gods (among others) and the source of the titans downfall, Hades, Poseidon, and Zeus (the youngest and conquerer of his father Cronus.)
They also had other immortal rivals such as Typhon.
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Zeus was the ruler of the Greek Gods and Kronos was the ruler of the Titans.
Gods have no enemies.
titans
In Greek mythology, Hermes, the messenger of the gods, did not have many outright enemies. However, he did have conflicts with Apollo, the god of the sun, music, and prophecy, over various matters, such as the invention of the lyre. Additionally, Hermes was known for his trickster nature, which sometimes caused tension with other gods and mortals. Overall, Hermes was more of a mischievous and cunning character rather than having specific enemies in mythology.
No. The Greek gods were just as important.