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I assume you mean the Renaissance, as the modern period does not begin until at least the 19th century. Here's my opinion:

1. European adaptation of gunpowder (revolutionized warfare)

2. Discovery of the Americas (revolutionized politics, empires, and daily life)

3. Fascination with antiquity (revolutionized art, culture, and architecture)

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Q: What were the three most significant changes that marked the end of the middle ages and the beginning of the modern period?
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