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- Martin Sheen (actor, father of Charlie Sheen and Emilio Estevez)
- Margaret Sanger (one of the founders of atheism
- Mike Singletary (current NFL coach, former Chicago Bear player, on Super Bowl winning team)
- Mary Steamvirgin (actress)
- Martin Short, comedian, actor
- Maggie Smith (actress)
- Morley Safer, long time 60 Minutes correspondent
- Mark Spitz, gold medal winning American Olympic swimmer, 1970's)
- Maria Shriver, journalist, first lady of California, part of Kennedy Family
- Martha Stewart, very successful business person, has magazine and TV show
- Michael Schumacher, auto racer
- Mary Shelley, author, most famous for writing the original Frankenstein novel
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