All of the above.
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If the question is asking about the Civil War battle with the highest death toll, I believe it was the Battle of Antietam.
The loss of approximately 620,000 soldiers borders on being the most costly loss of lives then most of America's losses in all wars fought by the US combined. The figures on this can vary, however, there is no doubt that the Civil War losses were huge compared to any other single war the US was involved in. Also, there is no dispute that the loss of lives in the Battle of Antietam, of approximately 25-27,000 casualties is the largest number in one day then in any other battle. The numbers are even more shocking when the populations, North and South in 1861- 1865, combined totaled some 32,000,000 people. In World War Two, with Americans fighting on two fronts, faced with death machines such as air plane bombers, tanks, machine guns, submarines and battleships, the American losses were about 405,000 between 1941 to 1945.
Military loses during the American Civil War == == Between 618,000 and 700,000 Americans died in the Civil War, The number most quoted is 620,000.This number exceed the nation's loss in all its other wars, from the Revolution through Vietnam.The Union armies loses are esimated at * Battle deaths: 110,070* Disease, etc.: 250,152* Total 360,222The Confederate Armys losses are estimated at * Battle deaths: '''94,000* Disease, etc.: '''164,000 * Total '''258,000
Loss of food, loss of homes, and poinoned water from dead boddies and ash from fires