While it is not known for sure, the total would be in the tens of thousands. About two thirds of the deaths in the Civil War was due to disease including gangrene.
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The American Civil War was the deadliest war in American History. About 620,000 individuals lost their lives during the Civil War. Confederate deaths were 260,000 of which 93,000 were killed in combat, while Union deaths were 360,000 of which 110,000 deaths were in combat. Disease was the major cause of death in the civil war. Out of 620,000 deaths, 417,000 were from diseases while 203,000 were killed in combat. In total deaths the American Civil War was the deadliest war in American History with over 620,000 fatalities. Although in combat related deaths World War II remains the deadliest conflict with 292,000 combat deaths (416,000 total). (see the related link)
The American Civil War was one of the deadliest wars in American History. As many as 620,000 individuals lost their lives during the Civil War, more than in any other war before or since.Confederate deaths were about 260,000 of which 93,000 were killed in combat, while Union deaths were 360,000 of which 110,000 deaths were in combat. Disease was the major cause of death in the civil war. Out of 620,000 deaths, over 400,000 were from diseases.In total deaths the American Civil War was the deadliest war in American history (although in combat related deaths, World War II remains the deadliest conflict with 292,000 combat deaths).Union Casualties : 110,000 killed in action360,000 total dead275,200 woundedConfederate Casualties :93,000 killed in action260,000 total dead137,000 woundedAll said, some 635,200 Union soldiers were killed or wounded, and 397,000 Confederates were killed or wounded.
The greatest cause of death was disease 1( from when surgeons did not wash there instruments such as the bone saw.
Civil War (1861–1865) Total servicemembers (Union) 2,213,363 Battle deaths (Union) 140,414 Other deaths in service (nontheater) (Union) 224,097 Nonmortal woundings (Union) 281,881 Total servicemembers (Conf.) 1,050,000 Battle deaths (Conf.) 74,524 Other deaths in service (nontheater) (Conf.) 59,297 Nonmortal woundings (Conf.) unknown
Due to the ferocity of the fighting and destruction and chaos of the war, and the fact that neither side keep very accurate records it is impossible to say for sure. The best estimate is about 500,000 killed from all causes.