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Slave trade
It is not clear to what period or what kind of trade you are referring. If it's the trade after the discovery of the Americas the countries most involved were Spain and Portugal and later, England. If it's the transatlantic slave trade, the countries involved were England and the United States, and to a lesser extent Portugal and the Dutch Republic.
triangular trade
One factor was in the early 1800s, European nations began to outlaw the transatlantic slave trade.
1787 when a group of Quakers formed the Committee for the Abolition of the Slave Trade.