In the early days when the first industries were being built, most people thought the more industries that were built, the worse your industry would do. But with today's economy it's a good thing to have had those early industries to show us how supply and demand are some of the most important parts of industry today.
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Cotton had a major impact on slavery especially after Eli Whitney invented the Cotton Gin. As to Westward expansion farmers bought land in Alabama and Mississippi on which to farm cotton.
Colonists were upset that the king would restrict their expansion westward.
It made the issue even more prevalent. People had the decision to make a state free or a slave state.
Westward expansion had a negative impact on Native Americans. Their whole way of life was taken away from them, along with the freedoms they had always known. They were removed from their land and placed on small reservations. Families were separated, and much of their culture was lost as the government tried to assimilate them into the white ways of life.
The spread of European diseases had the greatest impact on Native Americans. Large numbers were wiped out by these foreign diseases they were unprepared to deal with.