During the time of the American frontier, settlers wanted to move west to live a more fruitful life. When they headed west, they were attacked by the Indians who often killed them and stole their horses, mules, and oxen.
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This question has several different answers. Some settlers were trappers and hunters, and as they moved across the plains they did so on foot or horseback. Other settlers were considered pioneers, and as they migrated west they would walk, pulling handcarts or use covered wagons pulled by teams of oxen. Later on as more people migrated west, they were able to go by train; the transcontinental railroad system.
most likely fear or as adventure
the west was offering land to the settlers
turnpikes... I think
Daniel Boone lead settlers through the 'Cumberland Gap' to forge the 'Wilderness Trail' to open up travel to the west.
As the settlers pushed back the indians, the "middle gound" also moved west.