They used it to go to the Appalachian Mountains
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to travel across the Appalachian mountains without having to go up and the Appalachian mountain
They used the National Road
Daniel Boone's Wilderness Road
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The Wilderness Road opened in 1775 when adventurer Daniel Boone blazed the trail the road followed. It went from Fort Chiswell in the colony of Virginia through the Cumberland Gap into part of central Kentucky.
The first highway in the US was the wilderness road.