The conflict between white settlers and Native Americans was unavoidable. The United States was bent on dominating the land from coast to coast. They sought territory, new homelands, the wealth of mining minerals and to increase the power of the USA in world affairs. This could only be done by creating a nation that was considered to be a member of the world community.
Sadly all this came at the expense of the Native Americans. They were run off their ancestral lands by large numbers of Federal troops and an overwhelming surge of white settlers headed West.
The entire "New World" became the realm of the immigrants from Europe. And as it was in the North American continent, the South American continent would produce similar but not exact results.
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Never good, but sometimes unavoidable - as when Britain had to react to Hitler's flouting of international treaties.
Lincoln's election win in 1860 - it meant there would be no new slave states, so if the South did not secede, they would always be outvoted in Congress.