Tobacco
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He is the man who invented cigarettes.
1848.
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James B. Weaver House was created in 1865.
After the civil war, the south did have some coal mines (mainly in Kentucky if you consider that south). But the number one Industry in southern states was tobacco. Especially in North Carolina where the American Tobacco Company was founded by James B. Duke (Founder of Duke Universtiy). The major difference between north industry and south industry was there were virtually no unions in the south.