If you are talking about the United States, this region is called the Prairie since the interior is grassland. However, the question does not specify which country's middle is being referenced and every country has a different term for its middle-region.
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Again, please define "the middle region."
The Middle Colonies: New York, New Jersey, Pennsylvania, Delaware.
California and like Colorado
New Hampshire is a functional region. It is one of the states in the United States and is located in the northeast region of the country.
The Middle Colonies is comprised of the middle region of the 13 colonies. Its geography include the states of New York, Delaware, New Jersey, and Pennsylvania.