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There was the Bozeman Trail, the Oregon Trail, the Mormon Trail and the California Trail that were all used for emigration west.
American settlers
It's really 2,000 miles long these other answers were so off it's not funny.
The Sante Fe and Oregon opened the American West by finding the best trails to California and Oregon. The Sante Fe Trail became a very important cattle trail. The Oregon Trail was populated by farmers for the most part.
Missouri and Columbia rivers