Christopher Columbus is the first European to sail to the America's.
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It is surmised that the first Europeans came from Viking backgrounds. An explorer named Leif Erikson visited the east coast of North America almost 500 years before Columbus.
The first people to visit North America were the Indians, or indigenous people, or first nations, as they are variously called.
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South Carolina was not "discovered" in the 1600s. The area that is now South Carolina was inhabited by indigenous peoples for thousands of years before European exploration. Spanish explorers were likely the first Europeans to visit the region in the early 1500s, but permanent European settlements were not established until the English arrived in the late 1600s.
It is generally thought by anthropologists that America was peopled by Asians who crossed a land bridge between what is now Siberia and Alaska many thousands of years ago. Studies of blood groups support this theory. As for Europe, the first Europeans to visit the Americas are thought to be the Norse peoples. The remains of their settlements can be found in northeastern Canada. It is thought that changing climate in the form of severe cooling and the increase in ice formation drove them out of the region. The increasing severity of the winters forced shorter summers (with narrow growing and grazing periods) on the immigrants, and ice blocking bays for longer periods isolated them to the point they could not sustain themselves.