The United States Government.
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civil war
Over competition for land.
Because the Spaniards wanted to convert the Indians to Christianity.
The Native Americans had land. The European Settlers wanted it. That is not just the "most likely" cause, that is the cause.
The U.S. took on Imperialism and therefore expanded across Noth America. There was war over land the French and Indian War, and then other tribes sold their lands and were moved to reservasions.