The first colonists were English settlers, wealthy landowners from the west indies, and enslaved Africans.
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North or South Carolina?
enslaved africans
There is no documented evidence of a first colony that moved west. Colonists from all over would move west if their resources ran low.
What was the first Battle in South Carolina and when was it?
Colonists found that many places were suitable for farming. By the 1750s, there were some farmers in Massachusetts, but the vast majority settled in the southern or Middle-Atlantic region, especially in Virginia, Maryland, South Carolina, and Georgia.