Import tariffs to protect American industry, which was nearly all in the North. It was the South that wanted cheap imports, but would be increasingly taxed on them.
The annexing of vast territories from Mexico, which many people believed should be free soil. This would have weakened Southern voting power in Congress.
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The event that determined the status of slavery during the 1850s was the Wilmot Proviso. It was also a major cause of the Civil War.
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There were 3022,427 slaves in Missouri in the 1850s