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It was used through the 1800s by explorers and settlers as a way to get through the Appalachian Mountains.
It became a large water system for Indian's westward movement.
Lots of places in the USA have claimed this as their nickname - the Cumberland Gap mountains, Oklahoma and Pittsburgh among them. Probably the modern contender for the title is St. Louis in Missouri, which boasts the tallest (man-made) monument in the USA, The Gateway Arch. The Gateway Arch is a symbol of the US expansion westward.
Daniel Boone
Thomas Walker newtest3
Daniel Boone lead settlers through the 'Cumberland Gap' to forge the 'Wilderness Trail' to open up travel to the west.