the spread of diseases from animals to humans.
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the answer is either the Agricultural Revolution or the 1700's
Tribal Era (Agricultural Revolution) Frontier Era (Lets conquer the wilderness) Early Conservation Era (lets preserve the wilderness) Environmental Era (60s- science, 70s- regulation, 80s- business)
Neolithic evidence of cultural sharing begins to appear around 8000-7000BC, with the start of the Neolithic revolution. Many groups began to work together organizing hunting parties, gathering foods, and creating pottery. Some even began to develop agricultural roots and domesticate animals.
The greatest problem that the Jamestown settler' had to face in the early years of settlement is disease and starvation.