It was true; the Spanish had weapons such as metal pikes, black powder firearms, and even horses.
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It was to discover as much as possible. New technology made it easier for people to discover things they never could before.
"Money" was his major motivation. His financial demands (10 percent of all earnings to be made in the lands to be discovered, among others) was considered so extravagant by the Portuguese that they refused to back his expedition. Another reason was that they had - correctly - calculated that India or China never could be found where Colombus thought he would find it. Columbus repeated his financial claims to the Spanish Court and reached an agreement. Only the Spanish Government never made good on its promises and Columbus spent the rest of his life in fruitless ligitation.
They never really tried to enslave the Native Americans. Th Spanish did use Native Americans as slaves in mines and missions. The African slave trade solved all labor problems.
The most potentially fatal danger was that Colombus and his crews on the three exploration ships furnished by the Spanish Crown would be victims of the Atlantic Ocean. Colombus had never attempted such a long voyage. They were in fact travelling into "uncharted waters".