It made the English King, not th epope, the offical head of England's church
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The Act of Supremacy established Henry VIII as not only the King of England but the head of the Anglican Church as well. This meant he did not have to answer to any religious ruler and had absolute power over decisions of both church and state in Britain. This power, in a time when the Pope controlled nearly everyone, was unprecedented.
If Queen Catherine's only child was a boy there wouldn't have been Reformation parliament or the Supremacy act. Also England wouldn't have had its first queen aka Queen Mary.
national law over state laws
Henry
The Anglo-Spanish War of the 1500s was a result of King Phillip the Second's suppression of the growth to the Protestant religion in Catholic Spain. It was caused by England's Act of Supremacy, which threatened the power of the Pope.