The greatest problem that the Jamestown settler' had to face in the early years of settlement is disease and starvation.
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The Austrio-Hungarian Empire faced the problem of war.
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being killed and eaten by cannibals
Some of the difficulties that they faced were being killed by wild animals, the heat, hostility from the slave trade and un-trustworthy guides.
Some challenges faced by early settlers in Australia were dense forests, clearing farmland by cutting trees, and finding food. The Aborigines were not very friendly to the newcomers either.