Columbus did not reach the mainland of the New World until his third voyage.
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The Spanish explorers wanted to find gold, silver and power.
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The Anglo-Spanish War of the 1500s was a result of King Phillip the Second's suppression of the growth to the Protestant religion in Catholic Spain. It was caused by England's Act of Supremacy, which threatened the power of the Pope.
The defeat of the Spanish Armada by the English Navy in 1588.