One thing is the Spanish Conquest lasted from 1519-1521.
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Charles VII became the holy Roman Emperor in 1519.
Hernado De Soto was attacked by a tribe of Indians in Alabama and were forced to kill many Indians to escape. His exploration group was attacked again when they demanded that another group of Indians give them 200 people to help their exploration.
1519- 1522
Cauhtemoc[Emperor] was a ruler of the Aztec empire from 1520 to 1521.He came to power in 1521.Cauhtemoc was defeated by the Spanish empire.Cauhtemoc was known as the Aztec empire at that time. He was known as the godlike ruler of the Aztec's.
Magellan's five ships left Spain on September 20, 1519.