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Mesopotamia is most important because it laid the groundwork for civilizations to exist. Prior to Mesopotamia, all cultures were nomadic hunter/gatherers. Settling in one area was impossible because irrigation had not yet been invented -- forcing societies to roam the lands for whatever food they could find. By settling between the Tigres and Euphrates river, Mesopotamians were able to irrigate crops, and create a sustainable drainage system. This allowed for a stable production of food, making the nomad way obsolete. This paved the way for the Mesopotamians to focus on other important aspects such as a writing system, laws, etc.

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Mesopotamia literally means "Middle land" it was extremely fertile like the Nile river and was used for transportation and trading. But unlike the Nile, its flooding was unpredictable, and because outsiders wanted the fertile land and it was conquered by about 8 times I think. If this is what your asking, I'm sory if it isn't.

They used it for farming as well.

Source: I know this.

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Q: What is important about Mesopotamia?
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