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Christopher Columbus reached North America in 1492 and came back to Spain to report his discovery and so alerted Europe to the New World and began a fury of voyages of exploration and the founding of settlements by Spain , Portugal, the Netherlands, France and England. Viking ships had reached North America before Columbus but this information was not known in Europe outside of Scandinavia.
French and Indian War
Yes, the United States of America were, in aggregate but still in plural, first given international recognition as independent states by the Treaty of Paris in 1783. The first nation to grant recognition to the "United States of America in Congress" was Morocco in 1786. It was not until after the ratification of the US Constitution in 1789 that the US began to gain international recognition as a single independent country. The Treaty of London of 1794 (also known as the Jay Treaty) was a significant milestone in that process.
Japan
Native American civilizations from the Inca empire to the Native Tribes of North America were threatened first by fighting amongst themselves. For example, the Incas conquered lesser tribes when building their empire.But, the huge & overwhelming threat and ultimate conquest began when the first Europeans began to colonize the entire Western Hemisphere.