The 9th President of the United States William Henry Harrison was the first to die in office in 1841 only 32 days into his term.
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Their choice of vice-president would take office as the new president if the president-elect should die.
Yes ,William Henry Harrison was the first president to die while in office. He died in the White House after catching a cold.
Millard Fillmore
The assistant president will be sworn into office.
Second in line to the presidency is the Speaker of the House.