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In 1541, Hernando De Soto reached the Mississippi via a route close to modern day Tennessee. He and a group of 400 then proceeded to canoe down the river at night to avoid Native American attacks. He ended his trip in modern day Arkansas, failing to discover the City of Gold he sought.
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TaigaSpanish explorer Hernando de Soto was the first European to discover the river in 1541. French explorers Louis Jolliet and Jacques Marquette traveled down it in 1673 as far as the Arkansas River. French explorer La Salle reached the delta in 1682 and claimed the entire Mississippi region for France, as Louisiana. France kept control over the upper river, but the lower portion passed to Spain in 1769.
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