That depends on what you mean by 'event' and 'life'. The greatest loss of life on earth was the Permian-Triassic extinction event, which occured 252 million years ago. The greatest loss of human life in a single event could be defined with World War II, the death toll of which, at its highest estimate, is roughly 72 million dead. But the greatest loss of life in a single one time event is the atomic bombing of Hiroshima, Japan by the USAF in August 1945 which resulted in the deaths of roughly 150,000 people in a single day, with many more dying of radiation poisoning and injuries in the days, months, and years to come.
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That depends on what you term an "Event" to be:
Natural Disasters:
Drought - Sichuan Province China 1936; 5 million people died
Flood - Huang He (Yellow River) China, 1931; 4 million dead
Epidemic - The Black Plague, 1340; 75 million people dead
Man Made events:
Bombing - Hiroshima 1945; 140,000 dead (estimate)
Genocide - United States 1492 to present day; Between 12 and 114 million Indians
Mass Murder (by individual) Thug Behrem 1790-1830; 931 known victims (all strangled by hand)
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Crispus Attucks was one of five people to be killed.
The Boston Tea Party was the most important event during the Revolutionary War.
"http://wiki.answers.com/Q/This_person_was_one_of_the_first_people_killed_in_the_cause_of_american_independence_who_is_it"
Alexander Hamilton was the most famous one to be killed in a duel. He was shot by Aaron Burr, the vice-president.
well it depends, hes probably killed over 1000 every one hates that fat pig