If you mean the character in Shakespeare's play, then this is what he did: He listened to the witches, killed Duncan the king of Scotland, then created a rebelion against him where Macbeth and Macduff fight to the death and Macbeth gets killed by Macduff, making Macduff's son Michael the king of Scotland.
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One of the bad things of isolationism is that it can lead to bad things happening in other countries. These bad things can at some point impact your own country. Another bad thing about it is that it can lead a country to not really understand what is happening in other parts of the world. This can be dangerous.
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My psychic prediction for the year 2010 is that many things will happen, and among these many things will be some good things and some bad things. Some people will die, and other people will be born. And so forth.
When you play an Oulja board there is a 40% chance that the bad spirits will haunt you and do so many bad things to you and you could possibly die....