William Henry Harrison was the President known as Old Granny. He was given the nickname by Democrat detractors to give the impression that he was old and out of touch with the nation.
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As of June 2014, no U.S. President was nicknamed "Big Bill." William Howard Taft was nicknamed "Big Chief" and "Big Lub."
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Ronald Reagan
Little Ben was a nickname that was given to our 23rd President, Benjamin Harrison,
Upon the death of President Harrison, John Tyler became the first vice president to assume the presidency. Tyler was nicknamed "His Accidency" by opponents because he seemed to gain the presidency by an accident of fate versus being elected to the office.