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No nephew of a US President has ever been President.
However, in the case of Franklin Delano Roosevelt (32nd US President), his wife was the niece of a President. FDR married his fifth cousin, once removed, Eleanor Roosevelt, and her uncle (also his distant cousin) was Theodore Roosevelt, the 26th US President.
Only two sons of Presidents ever became President:
John Quincy Adams (6th President) was the son of John Adams (2nd President)
George W. Bush (43rd President) is the son of George H. Bush (41st President)
Benjamin Harrison (23rd President) was the grandson of William Henry Harrison (9th President).
No US President was ever the nephew of another US President. However, President Franklin Delano Roosevelt (in office 1933-1945) was married to his fifth cousin Eleanor Roosevelt, and heruncle was President Theodore Roosevelt (in office 1901-1909).
Many, if not all of the presidents were uncles. Any man whose siblings have children is an uncle. George Washington, Franklin Roosevelt Gerald Ford, Bill Clinton, and Barack Obama are the only presidents to have only half-siblings.
None of the presidents was the uncle of a U.S. President. However, President Franklin Delano Roosevelt (in office 1933-1945) was married to his fifth cousin Eleanor Roosevelt, and heruncle was President Theodore Roosevelt (in office 1901-1909). On the other hand, several presidents were the son of a former president: John Adams and his son John Quincy Adams; and George H.W. Bush and his son George W. Bush.
The 23rd President, Benjamin Harrison, was the grandson of the 9th President, William Henry Harrison.
The 4th president, James Madison, had several nephews. None are particularly well-known.
Benjamin Harrison
If you are asking what president was the grandson of a president, the answer is Benjamin Harrison, grandson of Wm. H. Harrison. Of course, lots of other people have been grandsons of presidents.
Benjamin Harrison who was the only president elected out of Indiana was the grandson of William Henry Harrison.
John Tyler
The first grandchild born in the White House was Thomas Jefferson's grandson, James Madison Randolph, born to his daughter, on January 17, 1806 . ( The first girl grandchild was John Quincy Adams' granddaughter.)