The environment guided the shaping of the cultures and societies - Apex
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With the understanding that Mexico is in North America, Native Americans did not have the diseases that Europeans brought to the New World. Also, horses and the wheel were not in the Native American empires and Tribes.
A treaty signed in 1763 gave Great Britain control of most eastern North America
The Great Plains.
The economic activity in the most densely populated parts of North America is in the medical field. There are cosmetic as well as necessary medical procedures performed in great numbers anywhere where there are a lot of people.
The Ohio River valley, the Mississippi river valley, and the entire great lakes region