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There are a number of reasons why the Mesopotamia area was settled. This main reason was the civilization and the trade activities in the area among other things.
the people who had settleed in the southern mespotamia were the sumerains.
The Arab invaders who settled in Mesopotamia and Spain.
Mesopotamia was found in the area between the Tigris and Euphrates rivers. currently, the area is made up of Iraq and Kuwait, and portions of Iran, Turkey, and Syria.
China, India, Egypt, Babylonian Empire (established in the Mesopotamia area, see: http://en.wikipedia.org/wiki/Mesopotamia)
Mesopotamia was around before written history. However, archaeological remnants in the area suggest the civilization was around before 8000 B.C.