economic conditions and interests in each region varied
Going back as far as the colonial era the northern and southern regions of America had differed greatly economically. The northern states were based mostly in manufacturing, trade and some agricultural production, while the southern states were vastly agricultural. These early differences also help account for the rapid growth of slavery (in agriculture) in the south and its low incidence in the northern regions. These sectional and economic differences continued to divide the nation and helped contribute to the eruption of the Civil War in 1861.
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Because most of the industries were established in the North, whose economy was largely based upon the production and trade of industrial products, while the economy of the South was mostly based upon monoculture and crops developed by slaves' labour. Therefore the North needed a massive employment of more and more specialized manpower, which had to live in the vicinity of the factories, thus growing the size of the cities. The South needed instead more and more land to exploit its agricultural production.
Wilson's Creek was the only major pitched battle. But Missouri was a deeply divided state, and there was terrible guerrilla warfare throughout the conflict - largely because of the circumstances that led to Wilson's Creek.
The conservtive reaction to counter culture in the 60s was largely ineffective
Switzerland remained neutral because it was largely inaccessible - very difficult to attack and occupy. Netherlands and Belgium remained neutral for the opposite reason - they were too accessible from either side.
There are some disagreements about why President Lincoln and the Northerners were willing to fight a war to save the country instead of letting the South secede peacefully. It may have been because the United States was largely seen as a political experiment and they didn't want to see it fail.