Nukes.
The aggressive ideology of the Communists International (ComIntern) to achieve world wide communist hegemony by means of revolutionary struggle and wars of "liberation" was the fundamental cause of the Cold War.
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The communists wanted to spread communism around the world, one way or another, and non-communists wanted to stop them.
Ideological differences did not cause the cold war. Nuclear Weapons caused the cold war.
the cold war
The main "isms" of the Cold War were Socialism and Communism, both of which came up against Capitalism.
The main cause of WW1 was the assassination of Archduke Franz Ferdinand.
the main cause is rapid population increase