It made slavery a central issue. It split the party into two factions.
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The Whig Party (whose final collapse was the result of the passage of the Kansas-Nebraska Act in 1854 - since Southern Whigs joined the Democrats in supporting it, but Northern Whigs opposed it)
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The ultimate goal was development of each mandate toward eventual independence.
The government used the Espionage Act to counter the loss of enthusiasm and opposition to the war at home. The act made it illegal to do, publish, or say negative that would hurt the war effort.
Douglas authored the Kansas-Nebraska Act which angered Northerners because it would make slavery legal in the two aforementioned states. This act was the main cause for the formation of the Republican Party. With the Republican party came the election of Lincoln, resulting in the secession of many southern states.