Settlers at the time did not want to move out west into uncharted territories. Many had families and the conditions and unfarmable, for the most part, land where not things they wanted to take on.
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being able to shoot a gun and attack. they might also need direct a ship.
to try to teach the native Americans Christianity. to get gold and silver and to make munny
The Kickapoo Indians signed away most of their land in Illinois in 1819.
During the time when North America was still being settled by European colonists, it was possible for settlers to go west and to claim land. The east coast was the first part of North America to be colonized by Europeans (being closest to Europe), so that land was the first to be claimed. After all the land was claimed in the east, there remained land in the west, still available to be claimed (given that the prior claims of native Americans were generally ignored).
When you do something with as little waste as possible.