Though the Spice Trade began as early as 3000 BCE, by the mid-1500s, its existence allowed European domination in the East. Until the mid-15th century, all European trade with the East was done via the Silk Road; however, once the Portuguese discovered routes around Africa to the East in 1488, the spice trade exploded. The European Age of Discovery, spearheaded by the Portuguese and developed by the Dutch, Spanish, and English, transformed the trade which allowed European traders to bring back spices such as cinnamon, black pepper, ginger, turmeric, and more into Europe.
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Many people traded while on the Silk Route but Ctesiphon was one of the most abundant places to trade at. The traded jewels, finery, perfumes, cosmetics, and rugs. Hope this helps ya! :)