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electrisity
It is probably impossible to argue what had the greatest impact on world history, it did of course have a massive impact and we still see its legacy now, but there are other things that have had an impact that is still with us (from the Roman Empire through to the Cold War). I think this probably counts as either a question that cannot be answered, or one that should be answered simply as "No".
The development and use of the microchip, leading to computers and cell phones.
Spain had the greatest impact on Latin America.
He made a quick judgment about the British and decided that their destruction was cause the greatest revolution in the history of the German Federal Government.