Different people affected the Church at different times. Possibly most consistently in the West it was the Pope, and in the East it was the Patriarch of Constantinople.
Other people who had profound influence included Kings of Franc and Emperors of the Holy Roman Empire. If there was a single person outside the Church of the Middle Ages who had the greatest effect on the Church, it might have been the Islamic prophet Muhammad, but people might disagree.
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It affected the holy roman empire by German emperors tried to control the church officials, nobles and popes. In which revolved into conflicts when it was time to select certain church official, and monarchs.
World War I and II, and the atomic bomb were the big events of the twentieth century. The two events that may have affected the course of the history of the world were the bubonic plague and European colonization of everywhere outside of Europe.
Well as you know Europe was a very wealthy , powerful continent at the time and it still is .and most of the wars affected all of Europe and all of thee states since most of europe such(as the French ) were our allies in war and we there's. Hope that helped you out a bit :)